chem

synthesis

AZP2006 (N-(3-(4-(3-(diisobutylamino) propyl) piperazin-1-yl) propyl)-1H-benzo[d]imidazol-2-amine disulphate salt;

INN: ezeprogind)

https://pubchem.ncbi.nlm.nih.gov/compound/Ezeprogind

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

Melnyk P, Vingtdeux V, Burlet S, Eddarkaoui S, Grosjean ME, Larchanché PE, Hochart G, Sergheraert C, Estrella C, Barrier M, Poix V, Plancq P, Lannoo C, Hamdane M, Delacourte A, Verwaerde P, Buée L, Sergeant N.

ACS Chem Neurosci. 2015 Apr 15;6(4):559-69. doi: 10.1021/cn5003013. Epub 2015 Feb 6.

download :

2015 melnylacs chem neurosci 2015 vol6 p559 569 (12.31 Mo)

Le brevet original :

https://patentscope.wipo.int/search/fr/detail.jsf?docId=WO2006051489