29 C R Acad Sci
[Immunocytochemical study at the ultrastructural level of neurofibrillary degeneration in Alzheimer's disease]. Defossez A, el Hachimi K, Beauvillain JC, Perre J, Delacourte A, Foncin JF. C R Acad Sci
Mode texte
C R Acad Sci III
. 1987;304(9):217-22.
[Immunocytochemical study at the ultrastructural level of neurofibrillary degeneration in Alzheimer's disease]
[Article in French]
A Defossez, K el Hachimi, J C Beauvillain, J Perre, A Delacourte, J F Foncin
PMID: 3102001
Abstract
Paired Helical Filaments (PHF), as demonstrated at the ultrastructure level, are one of the main pathological landmarks of Alzheimer's disease (AD). A polyclonal rabbit antiserum raised against PHF had been shown to label tangles and the periphery of plaques at the light microscope level. The same antiserum labels PHF specifically at the ultrastructure level, as demonstrated with a postembedding immunogold technique. Normal cytoskeleton constituents and plaque amyloid were not labelled. Specific labelling of a characteristic landmark may be a clue for a biological marker of AD.